Sleep disturbances in Phenylketonuria: an explorative study in men and mice.

Marijke Gordijn is coauthor of a study investigating sleep disturbances in PKU. Sleep problems have not been directly reported in phenylketonuria (PKU). In PKU, the metabolic pathway of phenylalanine is disrupted, which, among others, causes deficits in the neurotransmitters and sleep modulators dopamine, norepinephrine, and serotonin. Understanding sleep problems in PKU patients may help explain…

Sleep as part of a healthy lifestyle

What is sleep? Sleep as part of our daily life, This chapter describes the basic principles of sleep and wake regulation, the effects of sleep deprivation due to a mismatch between sleep and the biological clock, and what you can do about it. Every evening, a large behavioral change occurs in almost all people. In…