Tips to improve the regularity of daily routines, even when nothing about your life feels regular!

The COVID-19 pandemic poses a serious health threat to the world population. In response, governments are implementing a variety of new policies including self-quarantine, self-isolation and social distancing. While medically necessary to limit spread, these new social policies can disrupt many of the stabilizing factors in our lives which support mental health. In close collaboration,…

Educational paper published on Chronotherapeutic interventions

Chronotherapeutic interventions Marijke Gordijn of Chrono@Work co-authored a Dutch paper on Chronotherapeutic interventions in Psychiatry. She wrote this paper together with 3 colleagues with whom she also started Chronotherapy Network Netherlands (www.cnn.nl). The paper was published in the continuing education journal Psyfar. Since 2006, Psyfar focusses on educating and testing psychiatrists, hospital pharmacists, geriatrics specialists,…

Presentation: Introduction to Chronotherapy

Marijke Gordijn CEO of Chrono@Work will give a lecture on Wednesday, July 13th at the satellite symposium entitled ARE MOOD DISORDERS CHRONOBIOLOGICAL DISORDERS? This satellite symposium is organized by the Society for Light Treatment and Biological Rhythms on the first day of the 18th Annual Conference of The International Society for Bipolar Disorders (ISBD16) held…

Human cellular differences in cAMP – CREB signaling correlate with light-dependent melatonin suppression and bipolar disorder

Gaspas L., Van de Werken M., Johansson A.S., Moriggi E., Owe-Larsson B., Kocks J.W.H, Lundkvist G.B., Gordijn M.C.M., Brown S.A. Human cellular differences in cAMP – CREB signaling correlate with light-dependent melatonin suppression and bipolar disorder. European Journal of Neuroscience, 40: 2206-2215 (2014).

DOI:10.1111/ejn.12602

Human cellular differences in cAMP – CREB signaling correlate with light-dependent melatonin suppression and bipolar disorder

Various lines of evidence suggest a mechanistic role for altered cAMP-CREB (cAMP response element – binding protein) signaling in depressive and affective disorders. However, the establishment and validation of human inter-individual differences in this and other major signaling pathways has proven difficult. Here, we describe a novel lentiviral methodology to investigate signaling variation over long periods of…