The results of our study on the effects of near-infrared light (NIR) on health and well-being in people suffering from sleep loss is published today. In a double-blind, randomized, placebo-controlled study, the effects of three NIR light (850 nm) doses (1, 4, or 6.5 J·cm−2) were examined against the placebo. Exposure was presented five days per week between 9:30 am and 12:30 pm for four consecutive weeks. The study was conducted in both summer and winter to include seasonal variation. The results showed PBM treatment only at 6.5 J·cm−2 to have consistent positive benefits on well-being and health, specifically improving mood, reducing drowsiness, reducing IFN-γ, and resting heart rate. This was only observed in winter. No significant effects on sleep or circadian rhythms were noted. This study provides further evidence that adequate exposure to NIR, especially during low sunlight conditions, such as in the winter, can be beneficial for human health and wellness. In the upcoming year we hope to continue doing research on this topic to understand how the systemic effects are reached. https://www.mdpi.com/2039066