This study examined associations of chronotype and age with shift-specific assessments of main sleep duration, sleep quality and need for recovery in a cross-sectional study among N ¼ 261 industrial shift workers (96.6% male). Logistic regression analyses were used, adjusted for gender, lifestyle, health, nap behaviour, season of assessment and shift schedule. Shift workers with latest versus earliest…
Gaspas L., Van de Werken M., Johansson A.S., Moriggi E., Owe-Larsson B., Kocks J.W.H, Lundkvist G.B., Gordijn M.C.M., Brown S.A. Human cellular differences in cAMP – CREB signaling correlate with light-dependent melatonin suppression and bipolar disorder. European Journal of Neuroscience, 40: 2206-2215 (2014).
Various lines of evidence suggest a mechanistic role for altered cAMP-CREB (cAMP response element – binding protein) signaling in depressive and affective disorders. However, the establishment and validation of human inter-individual differences in this and other major signaling pathways has proven difficult. Here, we describe a novel lentiviral methodology to investigate signaling variation over long periods of…
