Sleep disturbances in Phenylketonuria: an explorative study in men and mice.

Marijke Gordijn is coauthor of a study investigating sleep disturbances in PKU. Sleep problems have not been directly reported in phenylketonuria (PKU). In PKU, the metabolic pathway of phenylalanine is disrupted, which, among others, causes deficits in the neurotransmitters and sleep modulators dopamine, norepinephrine, and serotonin. Understanding sleep problems in PKU patients may help explain…

Sleep as part of a healthy lifestyle

What is sleep? Sleep as part of our daily life, This chapter describes the basic principles of sleep and wake regulation, the effects of sleep deprivation due to a mismatch between sleep and the biological clock, and what you can do about it. Every evening, a large behavioral change occurs in almost all people. In…

Educational paper published on Chronotherapeutic interventions

Chronotherapeutic interventions Marijke Gordijn of Chrono@Work co-authored a Dutch paper on Chronotherapeutic interventions in Psychiatry. She wrote this paper together with 3 colleagues with whom she also started Chronotherapy Network Netherlands (www.cnn.nl). The paper was published in the continuing education journal Psyfar. Since 2006, Psyfar focusses on educating and testing psychiatrists, hospital pharmacists, geriatrics specialists,…

Review paper on Seasonal affective disorder, winter type.

Seasonal affective disorder, winter type: current insights and treatment options Marijke Gordijn from Chrono@Work co-authored a review paper on Seasonal Affective disorders. Seasonal affective disorder (SAD), winter type, is a seasonal pattern of recurrent major depressive episodes most commonly occurring in autumn or winter and remitting in spring/summer. The syndrome has been well-known for more…