Sleep disturbances in Phenylketonuria: an explorative study in men and mice.

Marijke Gordijn is coauthor of a study investigating sleep disturbances in PKU. Sleep problems have not been directly reported in phenylketonuria (PKU). In PKU, the metabolic pathway of phenylalanine is disrupted, which, among others, causes deficits in the neurotransmitters and sleep modulators dopamine, norepinephrine, and serotonin. Understanding sleep problems in PKU patients may help explain…