Gaspas L., Van de Werken M., Johansson A.S., Moriggi E., Owe-Larsson B., Kocks J.W.H, Lundkvist G.B., Gordijn M.C.M., Brown S.A. Human cellular differences in cAMP – CREB signaling correlate with light-dependent melatonin suppression and bipolar disorder. European Journal of Neuroscience, 40: 2206-2215 (2014).
Various lines of evidence suggest a mechanistic role for altered cAMP-CREB (cAMP response element – binding protein) signaling in depressive and affective disorders. However, the establishment and validation of human inter-individual differences in this and other major signaling pathways has proven difficult. Here, we describe a novel lentiviral methodology to investigate signaling variation over long periods of…
Knapen S.E., Van de Werken M., Gordijn M.C.M., Meesters Y. The duration of light treatment and therapy outcome in seasonal affective disorder. Journal of Affective Disorders, 166: 343-346. (2014).
Background: Seasonal affective disorder (SAD) is characterized by recurrent episodes of major depression with a seasonal pattern, treated with light therapy (LT). Duration of light therapy differs. This study investigates retrospectively whether a single week of LT is as effective as two weeks, whether males and females respond differently, and whether there is an effect of expectations as…
